The Federal Aviation Administration issued a safety notice Sunday urging U.S. airlines and aircraft operators to exercise caution when flying to or over Saudi Arabia as military activity and navigation system interference raise concerns about aviation safety in the region.

The FAA warning follows strikes on Riyadh’s international airport on Saturday and Sunday. The attacks reportedly killed 13 people and wounded more than 300, underscoring the potential danger facing commercial aviation as regional hostilities continue.

The agency warned that the threats could affect aircraft at every altitude, including during overflights, arrivals and departures. The notice, which remains in effect through Dec. 10, described the situation as potentially hazardous and applies to operators of U.S.-registered aircraft as well as U.S. airlines.

Riyadh’s airport remains closed to flights through at least 5 p.m. EDT Monday, creating uncertainty for carriers planning service to the Saudi capital.

The warning also raises questions about Delta Air Lines’ planned launch of direct flights between Atlanta and Riyadh on Oct. 23. Delta CEO Ed Bastian said last week that safety would determine whether the airline proceeds with the launch.

“Safety is going to make the call,” Bastian told CNBC. Delta did not immediately respond to a request for comment Sunday.

Other major U.S. airlines serve Riyadh through codeshare agreements with partner carriers, meaning disruptions could affect connecting travel even when American airlines do not operate the flights themselves.

Cargo operations could also face complications. FedEx launched its first dedicated flight into Saudi Arabia in September 2025, operating a Boeing 777 freighter six times per week. The service connects the Americas and Europe to Riyadh, with onward connections to Guangzhou and Shanghai.

The FAA’s warning highlights the challenges facing commercial airlines operating near active military activity, where attacks and navigation system interference can create risks beyond the immediate targets of hostilities. Airlines will have to weigh those concerns against their planned schedules as the security situation develops.