The U.S. Coast Guard is conducting a search off the coast of Nantucket, Massachusetts, for a missing medical evacuation jet that disappeared early Saturday morning while flying from Bermuda to Boston.

The Gulfstream G100, operated by Hamilton, Ontario-based Latitude Air Ambulance, departed L.F. Wade International Airport in Bermuda around 12:41 a.m. EDT with six people aboard, including two pilots, two medical staff members, a patient, and a family member escort. The four crew members are Canadian, while the two passengers are Bermuda nationals.

The Federal Aviation Administration lost contact with the aircraft around 1:30 a.m. EDT after it had been cruising at 24,000 feet. Flight tracking data showed the plane descended more than 13,000 feet in about two minutes shortly before contact was lost.

The Coast Guard Northeast District said air and surface assets, including planes, a helicopter, and boats, are searching the area south of Nantucket. The agency received a search and rescue alert from the FAA around 1:20 a.m. EDT.

Latitude Air Ambulance confirmed the plane's disappearance and notified authorities. Company officials said they are maintaining optimism while cooperating with rescue efforts. The aircraft had previously flown from Hamilton to Bermuda on Friday evening.

Boston Logan International Airport, the jet's intended destination, reported that the plane did not arrive as scheduled. Massachusetts Port Authority officials expressed thoughts for those on board and their families.

The National Transportation Safety Board is gathering information on the incident. Search operations continue into Saturday night with multiple vessels and aircraft involved.